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Public release date: 31-Oct-2012[ | E-mail |
Share ] Contact: Tim Parsons
tmparson@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
A new study from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that chronic kidney disease and its complications were associated with a higher risk of death regardless of age. The findings were presented October 30 at the American Society of Nephrology conference in San Diego, Ca. and published in latest issue of JAMA.
Chronic kidney disease prevalence increases dramatically with age from 4 percent at age 20-39 to 54 percent of adults over age 75 in the populations studied. This led some groups to question whether kidney disease at older ages is associated with increased risk and even whether the accepted definition of chronic kidney disease should be changed. Kidney disease is measured by estimating kidney function (glomerular filtration rate, GFR), and kidney damage is often quantified by measuring albumin, the major protein in the urine standardized for urine concentration.
According to the study, both low kidney function and high albuminuria were independently associated with mortality and end-stage renal disease regardless of age. Among the general populations examined and groups at high risk for kidney disease, the study found that relative mortality risk decreased with age in participants with low kidney function while absolute excess risk increased. For participants with high albuminuria, the reductions in relative risk were less apparent while increases in absolute risk were higher among older participants.
"By collaborating with many of the world's leading studies, we were able to see a clear pattern showing that both of the current indicators of chronic kidney disease are strongly associated with risk, even at older age," said Josef Coresh, MD, PhD, MHS, the Consortium's principal investigator and professor in the Bloomberg School's Department of Epidemiology.
For the study, researchers analyzed data from more than 2 million participants from 46 cohort studies conducted during 1972 to 2011. The study participants included a diverse population from Asia, Australia, Europe, and North and South America. Stein Hallan, a nephrologist from Norway, who led the writing of the manuscript on behalf of the 178 collaborating investigators said, "This analysis put to bed the controversy about kidney disease among older adults and the hypothesis that chronic kidney disease is so common at old age that it must be 'normal.' Instead we need to focus on the range of risks at each age and potential strategies to help patients minimize unnecessary exposure to medications toxic to the kidney and pursue other strategies to best treat kidney disease across the full age spectrum."
"Age and the Association of Kidney Measures with Mortality and End-Stage Renal Disease" written by the Chronic Kidney Disease Prognosis Consortium (CKD-PC), which includes approximately 200 collaborators and data from 40 countries.
###
The U.S. National Kidney Foundation and a variety of sources such as national institutes of health and medical research councils as well as foundations and industry sponsors supporting the authors and collaborating cohorts of the CKD-PC.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 31-Oct-2012[ | E-mail |
Share ] Contact: Tim Parsons
tmparson@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
A new study from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that chronic kidney disease and its complications were associated with a higher risk of death regardless of age. The findings were presented October 30 at the American Society of Nephrology conference in San Diego, Ca. and published in latest issue of JAMA.
Chronic kidney disease prevalence increases dramatically with age from 4 percent at age 20-39 to 54 percent of adults over age 75 in the populations studied. This led some groups to question whether kidney disease at older ages is associated with increased risk and even whether the accepted definition of chronic kidney disease should be changed. Kidney disease is measured by estimating kidney function (glomerular filtration rate, GFR), and kidney damage is often quantified by measuring albumin, the major protein in the urine standardized for urine concentration.
According to the study, both low kidney function and high albuminuria were independently associated with mortality and end-stage renal disease regardless of age. Among the general populations examined and groups at high risk for kidney disease, the study found that relative mortality risk decreased with age in participants with low kidney function while absolute excess risk increased. For participants with high albuminuria, the reductions in relative risk were less apparent while increases in absolute risk were higher among older participants.
"By collaborating with many of the world's leading studies, we were able to see a clear pattern showing that both of the current indicators of chronic kidney disease are strongly associated with risk, even at older age," said Josef Coresh, MD, PhD, MHS, the Consortium's principal investigator and professor in the Bloomberg School's Department of Epidemiology.
For the study, researchers analyzed data from more than 2 million participants from 46 cohort studies conducted during 1972 to 2011. The study participants included a diverse population from Asia, Australia, Europe, and North and South America. Stein Hallan, a nephrologist from Norway, who led the writing of the manuscript on behalf of the 178 collaborating investigators said, "This analysis put to bed the controversy about kidney disease among older adults and the hypothesis that chronic kidney disease is so common at old age that it must be 'normal.' Instead we need to focus on the range of risks at each age and potential strategies to help patients minimize unnecessary exposure to medications toxic to the kidney and pursue other strategies to best treat kidney disease across the full age spectrum."
"Age and the Association of Kidney Measures with Mortality and End-Stage Renal Disease" written by the Chronic Kidney Disease Prognosis Consortium (CKD-PC), which includes approximately 200 collaborators and data from 40 countries.
###
The U.S. National Kidney Foundation and a variety of sources such as national institutes of health and medical research councils as well as foundations and industry sponsors supporting the authors and collaborating cohorts of the CKD-PC.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-10/jhub-ckd103112.php
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Any advice is well recieved. I visited ER forms before and often read here only. However knowing there are many great folks here I pose this seneario. I fear my only family, the family thats left will be torn apart. Its inner family history repeating itself, a generation later. Again, If you can follow this, I'd appreciate any advice. My 2 cousins, my only family (plus their parents) lefts parents are still alive. My younger cousin is executor of their parents will. My older cousin has a physical disability and relies on my assistance, as I also am disabled, we rely on each other in a manor of speaking. She's concerned that her sibling will mis-allocate the will shes been given because her sisters deceased husband ,her deceased BIL's child already accused her sister of not distributing the will to the BILs child in the 50%/50% it was allocated. Both had a copy. The spouse of 2yrs kept everything, the will said 50% to her sister, 50% the BIL's child. This will went through probate too. Unfortunately i'm not well educated. This is the seneario another way. I'm assisting her with info. She feels her sister will misallocate what she can since she feels it was done before, w/o ramifications, she'll do it again. My input so far was see if she can get co-executorial designation in a codicil. The sister/executor lives with her 2X husbands child from another woman, whom is a CPA and her child from her first husband. I know its confusing, she needs *advice* assistance before its to late. The talking about money/will with her parents is awkaward generationally. She has a will leaving everything to her sisters kids, but her sister wants in on that too. I know MYOB, but this is family since birth. THANK YOU. 
I borrowed this moniker 
New Orleans, October 16, 2012 ? You walk into a bar and music is thumping. All heads are bobbing and feet tapping in synchrony. Somehow the rhythmic sound grabs control of the brains of everyone in the room forcing them to operate simultaneously and perform the same behaviors in synchrony. How is this possible? Is this unconscious mind control by rhythmic sound only driving our bodily motions, or could it be affecting deeper mental processes?
The results showed that when the image was flashed on that missed beat, the subjects identified the inverted image much faster than when the image was flashed at times out of synch with the beat or when the images were presented in silence. Somehow, the brain?s decision making was accelerated by the external auditory rhythm and heightened at precise points in synchrony with the beat. Since the power of rhythm in boosting cognitive performance was evident on the missing beat when no sound was presented, the effect could not have had anything to do with the sound of the drumbeat acting as a stimulus. Mental processing must have fallen into a rhythm of heightened expectation and superior performance on the anticipated beat.
The brain wave recordings also revealed a more surprising effect of rhythmic sound on brain function. Any sensory stimulus, such as seeing a picture or hearing a sound, will generate a brief brain wave in the region of cerebral cortex where such information is received and processed, much like the crack of a bat at home plate causes an eruption of cheers in a stadium. The researchers found that the sensory-evoked brain wave measured at the back of the skull over the region where vision is processed, peak each time the image was presented, but when the image was presented simultaneously with the missing drumbeat, the electrical response evoked by the picture was bigger than when the image was presented out of rhythm or flashed on the screen in silence. These visual circuits are more responsive when the image appears in synch with the auditory rhythm.