Chronic kidney disease increases risk of death at all ages

Public release date: 31-Oct-2012
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Contact: Tim Parsons
tmparson@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health

A new study from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that chronic kidney disease and its complications were associated with a higher risk of death regardless of age. The findings were presented October 30 at the American Society of Nephrology conference in San Diego, Ca. and published in latest issue of JAMA.

Chronic kidney disease prevalence increases dramatically with age from 4 percent at age 20-39 to 54 percent of adults over age 75 in the populations studied. This led some groups to question whether kidney disease at older ages is associated with increased risk and even whether the accepted definition of chronic kidney disease should be changed. Kidney disease is measured by estimating kidney function (glomerular filtration rate, GFR), and kidney damage is often quantified by measuring albumin, the major protein in the urine standardized for urine concentration.

According to the study, both low kidney function and high albuminuria were independently associated with mortality and end-stage renal disease regardless of age. Among the general populations examined and groups at high risk for kidney disease, the study found that relative mortality risk decreased with age in participants with low kidney function while absolute excess risk increased. For participants with high albuminuria, the reductions in relative risk were less apparent while increases in absolute risk were higher among older participants.

"By collaborating with many of the world's leading studies, we were able to see a clear pattern showing that both of the current indicators of chronic kidney disease are strongly associated with risk, even at older age," said Josef Coresh, MD, PhD, MHS, the Consortium's principal investigator and professor in the Bloomberg School's Department of Epidemiology.

For the study, researchers analyzed data from more than 2 million participants from 46 cohort studies conducted during 1972 to 2011. The study participants included a diverse population from Asia, Australia, Europe, and North and South America. Stein Hallan, a nephrologist from Norway, who led the writing of the manuscript on behalf of the 178 collaborating investigators said, "This analysis put to bed the controversy about kidney disease among older adults and the hypothesis that chronic kidney disease is so common at old age that it must be 'normal.' Instead we need to focus on the range of risks at each age and potential strategies to help patients minimize unnecessary exposure to medications toxic to the kidney and pursue other strategies to best treat kidney disease across the full age spectrum."

"Age and the Association of Kidney Measures with Mortality and End-Stage Renal Disease" written by the Chronic Kidney Disease Prognosis Consortium (CKD-PC), which includes approximately 200 collaborators and data from 40 countries.

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The U.S. National Kidney Foundation and a variety of sources such as national institutes of health and medical research councils as well as foundations and industry sponsors supporting the authors and collaborating cohorts of the CKD-PC.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 31-Oct-2012
[ | E-mail | Share ]

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health

A new study from the Johns Hopkins Bloomberg School of Public Health and the Chronic Kidney Disease Prognosis Consortium found that chronic kidney disease and its complications were associated with a higher risk of death regardless of age. The findings were presented October 30 at the American Society of Nephrology conference in San Diego, Ca. and published in latest issue of JAMA.

Chronic kidney disease prevalence increases dramatically with age from 4 percent at age 20-39 to 54 percent of adults over age 75 in the populations studied. This led some groups to question whether kidney disease at older ages is associated with increased risk and even whether the accepted definition of chronic kidney disease should be changed. Kidney disease is measured by estimating kidney function (glomerular filtration rate, GFR), and kidney damage is often quantified by measuring albumin, the major protein in the urine standardized for urine concentration.

According to the study, both low kidney function and high albuminuria were independently associated with mortality and end-stage renal disease regardless of age. Among the general populations examined and groups at high risk for kidney disease, the study found that relative mortality risk decreased with age in participants with low kidney function while absolute excess risk increased. For participants with high albuminuria, the reductions in relative risk were less apparent while increases in absolute risk were higher among older participants.

"By collaborating with many of the world's leading studies, we were able to see a clear pattern showing that both of the current indicators of chronic kidney disease are strongly associated with risk, even at older age," said Josef Coresh, MD, PhD, MHS, the Consortium's principal investigator and professor in the Bloomberg School's Department of Epidemiology.

For the study, researchers analyzed data from more than 2 million participants from 46 cohort studies conducted during 1972 to 2011. The study participants included a diverse population from Asia, Australia, Europe, and North and South America. Stein Hallan, a nephrologist from Norway, who led the writing of the manuscript on behalf of the 178 collaborating investigators said, "This analysis put to bed the controversy about kidney disease among older adults and the hypothesis that chronic kidney disease is so common at old age that it must be 'normal.' Instead we need to focus on the range of risks at each age and potential strategies to help patients minimize unnecessary exposure to medications toxic to the kidney and pursue other strategies to best treat kidney disease across the full age spectrum."

"Age and the Association of Kidney Measures with Mortality and End-Stage Renal Disease" written by the Chronic Kidney Disease Prognosis Consortium (CKD-PC), which includes approximately 200 collaborators and data from 40 countries.

###

The U.S. National Kidney Foundation and a variety of sources such as national institutes of health and medical research councils as well as foundations and industry sponsors supporting the authors and collaborating cohorts of the CKD-PC.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-10/jhub-ckd103112.php

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Lead Them Home: Boston Globe Coverage

Boston Globe columnist Joanna Weiss shared in the Boston Sunday Globe (10/28/12) about author and speaker Shari Johnson's journey to fully supporting her daughter's gay identity. Shari, an evangelical, is in town to speak at a Greater Boston PFLAG conference.?

Lead Them Home and PFLAG are each hosting conferences on preventing anti-gay bullying and gay teen suicide, both of which are featuring clinical social worker and researcher Dr. Caitlin Ryan of San Francisco State University. Interested in the "bridge" between evangelical and gay communities, Weiss contacted me curious about our work.

You can read the Boston Sunday Globe article here. We spoke moments before her publication deadline, so there was not significant coverage. For those interested in the entire interview, however, below is a transcript of the questions posed to me and my responses. I hope you enjoy it.?? ? ? ? ?1) How, when and why did you start your current ministry?

Lead Them Home was founded in 2003. I left a business career to devote full-time to our mission in early 2006. We help the conservative church better reflect Christ's love for LGBT people. I sensed this calling at the peak of culture war- in the midst of a huge divide between gay people and the church. We, the church, had utterly failed to reflect Jesus to gay people. That's our mission: to train and equip the church to reflect Christ's love to LGBT folks. We do this primarily through a church leader training called Posture Shift.

2) What do you find is the most useful, productive way to speak to Evangelicals about acceptance of their gay, lesbian, bisexual and transgender kids? Which methods of persuasion and discussion work best, and which methods don't work well at all?

I enjoy counseling evangelical families of LGBT loved ones, but our core mission is training pastors to become more effective in responding directly to these families. Many perceive that the church expects them to reject LGBT loved ones. Thankfully, the conservative church is realizing that damaging family relationships is no way to live out the Gospel. There is much work ahead, but many positive changes are well underway.?

It is important for these families to understand that I share their moral beliefs. Once they know I am not suggesting a shift in moral beliefs, then they are open to a "posture shift" away from rejection and toward acceptance. I tell them - you do not have to change your theology to love your gay children well. To gay teens and young adults, I stress that cutting off their parents hurts the entire family - including them. On both sides, rejection is damaging to family relationships.

The best way for evangelicals to embrace this "posture shift" is to listen closer to the stories of Jesus. Over and over again, Jesus gets angry at the religious leaders who propel people away from God. I try to let Jesus do the talking, but contextualize "the lepers" and "the outcasts" of his day to those who bear the brunt of religious people today. With the church's high pornography and divorce rates, we are the last ones who can target the bible against gay people. Does this change our beliefs? No. It does, however, radically change our posture. We must extend God's love to people where they are, because that is what Jesus has done for us. If we remember our own need for grace, it is much easier to freely offer God's grace to others. ? ?

3) What sort of reception have you received from both families and officials in Evangelical churches? Do a lot of people tend to shut you out, or do you come across a lot of people willing to listen and reconsider their beliefs?

Before I ever arrive, the church leaders I train already know they need help in relating to LGBT folks. In our 7th year, Lead Them Home is rapidly growing as church leaders wrestle between the truth they believe and the love they desire to offer. Fortunately, our Posture Shift training gives them biblical and practical answers. I do not see many evangelicals becoming "pro-gay" in their beliefs, but I do see many evangelicals becoming "pro-people" in their faith practice. That is great news - and yet we still have much work to do.

POST NOTE: To protect the integrity of Lead Them Home within the evangelical community, it is important to note that Shari Johnson sees the scriptures as approving of gay relationships. Lead Them Home holds to orthodoxy on this matter. It might be said that we have different beliefs, but our posture toward LGBT people is largely similar.? ? ?

?

JOIN THE CONVERSATION: Simply click the red comments link below. You may elect to comment as "Anonymous." Share this article on Facebook, Twitter, Buzz or by email. Reach Bill at (978) 212-9630.

Source: http://blog.leadthemhome.org/2012/10/boston-globe-coverage.html

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Photos: See a roundup of the day's best images

Tourists Alexandre Casias, center back, and Emilie Vachon, not in photo, from Montreal in Canada, have their car raided by Baboons, at Millers Point on the outskirts of Cape Town, South Africa, Wednesday, Oct 24, 2012. (AP Photo/Schalk van Zuydam)

Tourists Alexandre Casias, center back, and Emilie Vachon, not in photo, from Montreal in Canada, have their car raided by Baboons, at Millers Point on the outskirts of Cape Town, South Africa, Wednesday, Oct 24, 2012. (AP Photo/Schalk van Zuydam)

Source: http://news.yahoo.com/photos/photos-of-the-day-1340925511-slideshow/

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BACKCHAT!: Department of communications wraps up e-Skills ...

Department of communications wraps up e-Skills summit today

The Department of Communications through the e-Skills Institute will partner with the International Telecommunication Union Development Sector to host the Global Human Capacity Development Forum and the 2^nd e-Skills Summit from 22 to 25 October 2012 in Cape Town.? This year?s e-Skills Summit coincides and shares the same focus with the Global ICT Forum the Department of Communications together with the ITU decided to host both events jointly. The aim of Global ICT Forum is to draw attention to the need and importance of capacity building in driving the e-Agenda across different countries. We spoke to Dr Harold Wessels about what these e-skills are all about...

Source: http://bushbackchat.blogspot.com/2012/10/department-of-communications-wraps-up-e.html

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Singer Bobby Brown arrested in LA for drunken driving: police

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The top four rising Google Search terms during last night's debate: 1) Horses an...

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Stocks stabilize on Wall Street after a sell-off

NEW YORK (AP) ? The steep losses stopped Wednesday as the stock market turned calm, a day after one of its biggest sell-offs of the year. Indexes ended with slight losses after the Federal Reserve said the U.S. economy still needs support.

The Dow Jones industrial average closed down 25.19 points at 13,077.34, a day after one of its worst drops this year.

The Standard & Poor's 500 index fell 4.36 points to close at 1,408.75 while the Nasdaq composite index fell 8.76 points to 2,991.70.

"Today we're assessing the damage," said Mark Luschini, chief investment strategist at Janney Montgomery Scott. "Everybody just got clobbered yesterday."

Lower corporate revenue and expectations for the rest of the year drove the Dow down 243 points Tuesday, its third-biggest drop this year. DuPont, 3M, UPS and Xerox all reported lower sales than a year ago.

"It seemed out of the blue, but what we were seeing was stock prices adjusting to corporate profitability," Luschini said.

The market flitted between small gains and losses for much of the day. Indexes started to fade after 2 p.m., after the Fed repeated its assessment that the U.S. economic recovery remains modest at best.

At the end of its latest two-day meeting, the Fed said the economy is still expanding at just a "moderate pace" and that it needs time to see whether a new bond-buying effort launched in September will spur economic growth and new hiring.

Third-quarter earnings reports have mainly disappointed investors. The Dow has risen just one day in the last five, a gain of two points on Monday. It lost 205 on Friday following poor results from Microsoft, General Electric and McDonald's.

The latest batch of earnings reports wasn't as dire, and there was the occasional piece of encouraging news.

Facebook had its best day since its stock market debut in May. The company said late Tuesday that 14 percent of its advertising revenue came from mobile devices, allaying some investor concerns.

The social network's stock soared $3.73 to $23.23, a jump of 19 percent. Facebook has swung widely since its IPO at $38, and has traded as low as $17.55.

AT&T, which is part of the Dow average, said it added the fewest wireless customers since 2003, far behind Verizon Wireless. AT&T's results still managed to beat the estimates of financial analysts. AT&T slid 29 cents to $34.71.

A measure of manufacturing in China, the world's second-largest economy after the United States, improved this month to a three-month high. China's white-hot economic growth has been slowing.

Homebuilder stocks gained after the Commerce Department reported that sales of new homes jumped last month to the highest level in more than two years. Toll Brothers rose 70 cents to $35.25 and D.R. Horton rose 32 cents to $21.41.

A drop in profits for Norfolk Southern hit other railroad stocks. Norfolk Southern reported a 27 percent slump in quarterly earnings late Tuesday, as falling coal prices led to lower revenue. Many utilities have favored using cheap natural gas instead of burning coal this year, pushing down coal prices and weighing on railroad operators.

Norfolk Southern fell $4.92 to $61.09. Union Pacific lost $2.35 to $120.87.

Prices for U.S. government bonds inched lower, sending yields up. The yield on the benchmark 10-year Treasury note edged up to 1.79 percent from 1.76 percent late Tuesday.

Among other stocks in the news:

? Netflix dropped $8.10, or 12 percent, to $60.12. Late Tuesday, it slashed its prediction for how many U.S. video-streaming subscribers it would add this year to 4.7 million to 5 million. It had predicted it would add as many as 7 million.

? Dow Chemical rose $1.33 to $29.88. The company announced a wide-ranging restructuring plan late Tuesday that includes cutting 2,400 jobs and closing 20 manufacturing facilities. The company cited slowing economic growth in Europe and elsewhere.

? Tempur-Pedic International sank 20 percent after the maker of memory-foam mattresses reported revenue that was well below the estimates of Wall Street analysts. The company also cut its estimates for full-year profits and revenue. Its stock plunged $6.21 to $25.66.

Source: http://news.yahoo.com/stocks-stabilize-wall-street-sell-off-135610585--business.html

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